You will want to use DeNoise AI on Raw files first so that you can strip the file of Noise first thing BEFORE you sharpen the file.
This will do two things. It will take away the noise so that More Detail will be revealed Prior to Sharpening. You Do Not want Sharpened Noise to soften your pics.
After you do the DeNoise AI, Sharpen AI, etc. then do your PS/Lightroom magic and if the file is too small you may want to use Topaz Gigapixel AI on it.
PLEASE see the Topaz Ultimate Workflow link above! I have a hunch that the folks that came up with these wonderful products know a little more than I (we) do!?!
Also, I would just like to add that Topaz Products are non-destructive.
So you may apply, say DeNoise AI, to a jpg or Raw file and it will add a tag to the file so that the original file is never lost.
For example, a Raw (CR2, CR3, etc.) or JPG file when edited with DeNoise AI, Sharpen AI, etc. will change, depending on your choice) from:
IMG_123.JPG (or CR2/3/etc.) to
IMG_123-Denoise-XXX.DNG/PNG/TIFF/TIF and saved automatically as a separate file. You may even modify the file name to suit.
But your Original file will NEVER be lost.
I hope that this helps, so,
Smile,
JimmyT Sends
PS: I'm sorry if I beat your favorite horsie to death, sigh.