Yes, the Vaccine Will Be Diluted
Dec 20, 2020 08:58:03 #
Nothing new about the dilution. When I worked in clinics some of the meds would come in concentrated form, you just put in the correct liquid required and go on about your business. If somebody was getting a series of injections it would be ID just for them.
Dec 20, 2020 09:08:42 #
All vaccines have some overfill in the vial, whether liquid, frozen, or lyophilized. This is to compensate for the fact that it is impossible to retrieve 100% of the volume filled, small but normal variations in the fill syringe delivery, small but normal variations in the user's accuracy when removing the vaccine, etc, etc. It's always been this way and is perfectly normal. Some concentrated poultry vaccines are transported in liquid nitrogen and diluted 1000 fold or more just prior to use, and they are very effective.
Dec 20, 2020 09:35:01 #
machia wrote:
Why this dependence on automation?
And why are people doubting the ability of a trained person?
Pharmacists in pharmacies have mixed hundreds of millions of prescriptions over many decades. That’s what pharmacists do.
Perhaps the people who believe so heavily in automation also want the self driving car?
And why are people doubting the ability of a trained person?
Pharmacists in pharmacies have mixed hundreds of millions of prescriptions over many decades. That’s what pharmacists do.
Perhaps the people who believe so heavily in automation also want the self driving car?
Not a discussion about their ability so much as the ability to get "extra" doses.
I believe we all think they are quite able in their profession.
Dec 20, 2020 09:55:33 #
Paul J. Svetlik wrote:
It might be a rather beneficial for those, who would like to make a home-made covid-19 vaccine, I guess?
I've been looking online for homemade vaccines.
Dec 20, 2020 09:59:47 #
David Martin wrote:
It sounds like you think the manner of administeri... (show quote)
My experience with vaccines is limited to a needle in my arm. It's good to get info from people who know how they work.
I had a previous post, wondering about the vaccine, and I mentioned diluting it, not knowing that they actually do dilute it. When I saw this article, I thought I'd pass it along.
I don't have to look for things to worry about. They appear daily.
Dec 20, 2020 10:40:33 #
Dec 20, 2020 10:59:05 #
tshift wrote:
I think a little Jameson will do just fine. Thanks
Tom
Tom
Bushmill’s is equally effective and imho, a smoother flow thru the hypo.
Dec 20, 2020 11:28:27 #
ricardo00 wrote:
I assume there is a misprint/miss statement here, you can't take it out of the vial when it is frozen. They must have meant take "the vial out and defrost it". They then add saline to the whole vial before taking the individual dose.
I am sure Pfizer uses a robot to dispense the vaccine into the vial. However would you really want a robot to fill the syringe and inject it into your arm?
I am sure Pfizer uses a robot to dispense the vaccine into the vial. However would you really want a robot to fill the syringe and inject it into your arm?
AHHH common sense.Dec 20, 2020 11:45:51 #
Bultaco wrote: AHHH common sense.
AHHH common sense.
Something reporters no longer seem to have?
Dec 20, 2020 12:06:11 #
47greyfox wrote:
Bushmill’s is equally effective and imho, a smoother flow thru the hypo.
Since we are talking about mixing, what do you think about a little Bushmill's and Jameson together?? Thanks
Tom
Dec 20, 2020 12:54:42 #
jerryc41 wrote:
I posted a question about this a day or two ago - ... (show quote)
I think others have nailed it. Chemically, there is an equation for dilution that is based on the notion that the amount of solute (here, medication) remains the same regardless of the amount of dilution. A teaspoon of salt in 3 cups of water has the same amount of salt as a teaspoon of salt in a 5 gallon bucket. It seems the author edited poorly, effectively suggesting each dose could or would be used for multiple injections. As others have stated, I'm sure the original portioning of the doses is automated and that human error in dilution can't have an effect on the volume of medication, but only the volume of injection.
Dec 20, 2020 13:13:37 #
Tex-s wrote:
I think others have nailed it. Chemically, there ... (show quote)
Ahhh.
SAME AMOUNT of salt, yes,
but in TOTALLY different concentrations between adding to 3 cups and 5 gallons of water.
Do it and taste it, see which salt concentration is more palatable.
Dec 20, 2020 14:37:05 #
Tex-s wrote:
. . . human error in dilution can't have an effect on the volume of medication, but only the volume of injection.
Hmmm, think you don't quite have it. So if you don't mind, a little more clarification. An error in dilution would have an effect (ie. if the person put in 1 ml of saline instead of 0.5 ml that they were supposed to). Pfizer presumably shipped it in a way that optimized stability (often biological molecules are more stable when more concentrated or didn't want the vial too full in case of cracking the glass, etc) so have the preparer add a particular volume of sterile saline to dilute the medication to the correct volume. The amount of the injection is also carefully measured by taking it up in the syringe. However Pfizer presumably built in an extra volume (and amount of medication) so that if the person drawing up the syringe pulled in too much or had bubbles, they could squirt the extra out (which is thus wasted). If the people are careful drawing up the liquid, they will have this extra amount of vaccine in the vial which can then be used to inject an additional person.
Dec 20, 2020 15:02:39 #
ricardo00 wrote:
Hmmm, think you don't quite have it. So if you do... (show quote)
People also need to understand that to get the required dilution that ALL the required saline must be mixed prior to drawing the first dose. Not a portion of saline added for each draw.
I would not anticipate the "extra" in the vial to be a full dose.
Dec 20, 2020 15:09:36 #
jerryc41 wrote:
I've been looking online for homemade vaccines.
Without the dna chip eh! It is prudent to be sceptic and I am with You on that.
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