Merlin1300 Loc: New England, But Now & Forever SoTX

Imagine that :) :)
It was accepted by veterinarians working with pigs (that developed ulcers due to stress) for years before approved for use in humans that those ulcers were caused by a bacteria = H Pylori and came up with a non-surgical cure using gastric acid reducers (H2 blockers and Proton Pump Inhibitors {PPI}) along with antibiotics to kill the bacteria. This was resisted by physicians for years (IMHO as ulcer surgery was a cash cow for surgeons) until irrefutable evidence was presented. Of course now PPI + Antibiotics is standard of care for ulcers in humans.
https://en.wikipedia.org/wiki/Timeline_of_peptic_ulcer_disease_and_Helicobacter_pylori
-
Similar mechanisms may be delaying formal consideration of Ivermectin.

Merlin1300 Loc: New England, But Now & Forever SoTX

Ivermectin for humans is most commonly taken by mouth.
I believe the oral route is most commonly used for animals as well as it is easily administered by the rancher/farmer. Injectable versions are also available for use.

Merlin1300 Loc: New England, But Now & Forever SoTX

Ivermectin for human use is pretty universally available at pharmacies in the US, however requires a prescription from your physician. S/He would need to have read the manuscript presented in the first post, and agree to off-label use of the Ivermectin. You would probably need to sign an informed consent document that presented the various risks (IMHO these are minimal) versus benefits (Possible prevention of Covid-19 disease if exposed) for the use of Ivermectin. As previously mentioned, off-label use is both ethical And permitted provided there is evidence for potential benefit and there is no other definitively proven and widely accepted treatment protocol. IMHO waiting until a patient is at deaths door at a hospital is a bit too late to begin treatments - particularly when a known complication of Covid-19 (Cytokine Storm) can produce serious and long-term damage to major organs.

omar

You have to excuse us drug dealers, we get frustrated when some guy that sells pillows thinks he has the cure, or some guy who has the best healthcare in the world asks 'what have you got to lose?' (my life?). Ivermectin has not been proven to help so we like to be cautious. Also, it seems from some studies that part of the problem with a covid infection is that it stimulates the immune system which is why dexamethasone is used (to suppress) and that is why trying to boost the immune system may not be wise.

FranC

Thanks for the information but my reason for asking was as an investor, not a patient.

OleMe Loc: Montgomery Co., MD

NOT proven effective. Beware.

See https://www.covid19treatmentguidelines.nih.gov/antiviral-therapy/ivermectin/

Merlin1300 Loc: New England, But Now & Forever SoTX

I excuse you drug dealers as likely Not being the sharpest knife in the drawer.
I don't suppose you bothered to READ the manuscript ??
Can you understand statistics. Do you know what an RCT is ?? Do you have any qualifications to offer comments?
The manuscript contains data from RCT's as well as observational clinical studies.
It also includes what amounts to a meta-analysis suggesting Ivermectin MAY be helpful.
While the data may not be conclusive - it is certainly suggestive.
IF you get sick with Covid-19 - there are no guarantees with ANY therapy.
But given the low cost of Ivermectin, and the data presented, I know what MY first step would be. YMMV.

Merlin1300 Loc: New England, But Now & Forever SoTX

Ivermectin has been around forever. Unlikely it will gain any traction at this point, as vaccines are now available.

Merlin1300 Loc: New England, But Now & Forever SoTX

The NIH response is typical for a Govt agency (I was a federal employee x 36+ years).
They refuse to review the documentation submitted - merely dismiss it out-of-hand as NIH (not invented here).
Please do me the favor of reviewing the manuscript link in the original post.
If you lack the experience or qualifications to perform a critical review - find someone Independent who can, and will advise you before you post a critique. The NIH will NOT help you.
Oh - did I mention - - I do have an MPH from Harvard (as well as 3 board certifications in Preventive Medicine) ?

repleo Loc: Boston

Ivermectin is a medication used to treat many types of parasite infestations. This includes head lice, scabies, river blindness and threadworm. It is FDA approved for parasitic infections, but I think I will wait until they approve it for Covit.

TonyP Loc: New Zealand

Hi Merlin, have to admit I'm always a little skeptical about someone who claims to be an academic and has arrived here in a spaceship. But that's just me.
I wonder how much of the concoction you appear to be recommending derives its benefit from the Vitamin D, C and zinc content.

Dr Fauci admits he takes 8000iu of D3 a day, even tho the US RDA is something like 6000. Zinc of course is always a good supplement for them over 70ish, in careful amounts of course. Vitamin C is a great booster during winter anyway, when seasonal colds etc are prevalent.

As far as a magic vaccine goes, even the current crop of vaccines now have no guarantee that they will be effective in the face of recent Covid19 permutations that are being seen in the UK and Italy.
As an ex farmer, you wouldnt find me imbibing Ivermectin. But again, thats just me I guess. No accounting for taste.

My suggestion is that all good citizens of the US adopt personal responsibility:
Wear a mask, wash your hands frequently and adopt social distancing. Its been proven to work and doesnt require 'rocket science'.
We ignore the advice of history at our peril.

Merlin1300 Loc: New England, But Now & Forever SoTX

Hi Tony: Well - yes - - I am a rocket scientist - I helped develop the GPS 1976 - 78.
Although originally an astronaut candidate - I thought better of it after finding most astronauts wind up giving talks in elementary & junior high schools {only a rare few go on orbit} - and became a flight surgeon instead.
I do take 25 mg Zinc Gluconate, 1000 mg Vit C, 5000 iU Vit D per day. I should probably also take some Quercetin
Too much zinc on a chronic basis can be toxic - so be careful with that.
Fauci does have some academic chops - but he is also a politician - I do not trust him at all.
2 doses of the mRNA vaccines develop protective antibodies in up to 95% of recipients. Good enough for me.
As an ex-farmer, if you developed ulcers, would you undergo surgery, or take a PPI and antibiotics ??
Ivermectin for Covid-19 is certainly off-label at this time, but so was PPI and antibiotics for ulcer in the 1970's.
I have no stocks in Ivermectin production - but until I can get vaccinated - were I to test positive for Covid-19, I might seriously consider 18mg Ivermectin on days 1 & 3 until it is either disproven, OR a definitive similarly benign treatment (Hint - systemic steroids are NOT benign) for early Covid disease is overwhelmingly accepted and FDA approved.
Based on a small study (I posted earlier) regarding MMR-II and Covid resistance, my wife, 95 YO mother and I all took an MMR-II booster 4 weeks ago. 1 week ago we were all exposed to Covid-19. My wife and I tested negative, and mom is asymptomatic. Coincidence ?? Maybe.
Chloroquine and HCQ have now been shown by RCT as ineffective for Covid. The manuscript I posted in the original thread presents scientifically valid arguments for the possibility that Ivermectin might be helpful.
Regardless, I continue to Wear a mask, wash my hands and social distance.
-
Happy to post my {sanitized} academic certificates upon request.
-

Unless you were there, you don't get one of these

(Download)

TonyP Loc: New Zealand

Hi Merlin, just a quick reply before we head out to look at Christmas lights.
With all those qualifications and work experience, your avatar doesn't do you due credit, although I'm not sure of the relevance of being involved with GPS having anything to do with the subject under discussion.

You do infer some political bias by mentioning Dr Fauci, which leads me to an observation which may not win me friends here on UHH.
But I have to say, I think one of the reasons for the most advanced country in virtually any field one can mention, North America, having one of the the highest infection rates and death rates from Covid19, is because of the politicization of anything and everything.

New Zealands' success in eliminating the 'virus' to date has been predicated on a few very simple actions.
Our government, with the assistance of our top scientists and epidemiologists, followed the science.
Logic dictated wearing masks, practicing personal hygiene (as simple as washing ones hands with soap and water) and recognizing social distancing would limit the spread of a Virus including ordinary seasonal flu.
It worked.
Yes there was a price to pay but in retrospect it was a small price. Our economy is already showing fantastic signs of recovery. With a population of 5 million we had 25 deaths, mainly elderly or immuno compromised.
Not everyone agreed with the governments actions but most complied. Those that didnt were maily convinced they were being idiots by friends and neighbours. None were jailed or were otherwise punished.

Today our borders are open (albeit with managed quarantine) and its almost business as usual other than some export companies and tourism.
As a retired old man, my life is totally normal.

With the recent advise from other countries that the virus has mutated into a more virulent strain, how long this utopia lasts is anyones guess of course.

Really, this is just a long winded suggestion that I believe politics has played a big part in the horrific effect of the pandemic on the USA.
Regards

joecichjr Loc: Chicago S. Suburbs, Illinois, USA

Great, but the sanctioned treatments are the vaccines. That means if there is something else, much less dangerous and proven, that works, it's going to be pooh-poohed. Supporters will be ostracized. People will be forced to vaccinate regardless of the negative effects cropping up, which will be downplayed or not even reported. What would you choose - something relatively harmless and affordable that works, or a relatively unproven vaccine rushed in to production and possibly dangerous? You already know where we are being pushed...

Merlin1300 Loc: New England, But Now & Forever SoTX

Tony:1) Result of my 'tactical call sign' (Merlin) given by my base commander during a deployment in 1997
2) You mentioned arrival in a 'space ship' - so thought rockets might be a better choice. I landed the GPS job due to my Masters degree in electrical engineering - which gives me a leg up for analytical thinking.
3) Yes Fauci is a very political animal. I am not convinced all his recommendations are based on what's actually best for the people.
4) No quibble there.
5) IF I can prove I've been vaccinated, will NZ still require a tourist quarantine ?
-
Hope the X-Mas lights did justice to the wonder of the season.
Cheers :)