Merlin1300 Loc: New England, But Now & Forever SoTX

This is pretty darned interesting - but the mainstream hasn't jumped on board yet, having been burned by HCQ.
https://osf.io/wx3zn/
Statistics, OCT, RCT, Meta Analysis, included.

Post COVID-19 exposure prophylaxis***:
Ivermectin 0.2 mg/kg dose on day 1 and day 3
Vitamin D3 1,000–3,000 IU/day
Vitamin C 1,000 mg twice daily
Quercetin 250 mg/day
Melatonin 6 mg before bedtime (causes drowsiness)
Zinc 50 mg/day of elemental zinc

Early Outpatient Treatment Protocol (Covid Test +)****
MEDICATION RECOMMENDED DOSING
lvermectin 0.2 mg/kg x 1 dose on day 1 and day 3
Vitamin D3 4,000 IU/day
Vitamin C 2,000 mg 2–3 times daily and Quercetin 250 mg twice a day
Melatonin 10 mg before bedtime (causes drowsiness)
Zinc 100 mg/day elemental zinc
Aspirin 325 mg/day (unless contraindicated)

* Example for a person of 50 kg body weight: 50 kg × 0.15 mg = 7.5 mg (1 kg = 2.2 lbs)= 2.5 tablets (3mg/tablet). See table 6 for weight-based
dose calculations
** The dosing may be updated as further scientific studies emerge.

Although K9 and equine forms of Ivermectin are available, they are NOT for use by humans.

Mark Sturtevant Loc: Grand Blanc, MI

Interesting. The abstract in the link says it all. Agreed that caution is needed.

Merlin1300 Loc: New England, But Now & Forever SoTX

I too agree - but Ivermectin is pretty darn safe. It's been used by millions to prevent 'River Blindness' (Onchocerciasis) caused by parasitic worms primarily in sub-Saharan Africa.
https://www.cdc.gov/parasites/onchocerciasis/index.html

yssirk123 Loc: New Jersey

Haven't heard too much about treatments, but this one might be worth watching. Right now there's some cause for optimism, but it's too early to say.

https://www.youtube.com/watch?v=Tq8SXOBy-4w

Merlin1300 Loc: New England, But Now & Forever SoTX

Dr Pierre Kory testifying before a congressional hearing regarding off-label treatments for Covid-19: in particular, Ivermectin. He is one of the authors of the manuscript linked in my original post.

Scruples Loc: Brooklyn, New York

Before everyone runs to their doctor and begs for a prescription for ivermectin (Stromectol). I wish to caution all that this drug has an indications for treatment of parasites. It can also be used as an anti-inflammatory. It is currently used to treat the parasite Strongyloides mostly in this country. Please don’t dump all your stock in the mistaken belief and buy the other company’s stock. The studies were limited and not complete. Furthermore the use of a drug for a non-indicated and Non approved condition opens a doctor and a pharmacist to huge liabilities IF the treatment with the non approved drug goes south. Compassionate use (Emergency Use Approval) has only been granted for the vaccines At this time. As a pharmacist, this drug and hydroxychloroquine have limited effectiveness as an antiviral. The drug ramdesivir is an old AIDS drug that was abandoned more than 30 years ago. Studies of these drugs as antivirals were limited and not conclusive at the time they were done.
Any drug Or vaccine must be approved by the FDA before its use on a patient. The approval process is well established, tried numerous times and has numerous phases and then must be finally approved by an agency with so much at stake.
And to all the naysayers, if you think you can do a better job as Commissioner, step up to the plate.

yssirk123 Loc: New Jersey

That's an interesting and somewhat agressive reaction to posts about a possible treatment, which on the surface seems like it would be a good thing if it proves out. SMH.

Merlin1300 Loc: New England, But Now & Forever SoTX

(1) True - those are the primary FDA approved indications.
(2) The data presented were adequate to justify off-label use at this time.
(3) Not True - provided the physician obtains signature on a comprehensive informed consent document.
(4) False. Off label use is both ethical AND permitted provided possible evidence exists for the use prescribed.
-
I invite you to Google "Off-Label use of drugs". One of the returns follows. As a wound care physician, I successfully used boniva off-label (a bisphosphonate) to resolve a case of refractory calciphylaxis (an extremely painful and supposedly 'untreatable' consequence in some patients with long-term renal failure on dialysis).
https://www.pharmacytimes.com/contributor/timothy-o-shea/2016/01/10-surprising-off-label-uses-for-prescription-medications

braindamage Loc: Appley Bridge, Lancs, U.K.

Would Ivermectin cream, which I have been prescribed for Rosacea, provide any protection? I gram of crem provides 10mg of Ivermectin. Thanks.

jaymatt Loc: Alexandria, Indiana

I have been using Ivermectin for years to worm hogs, sheep, horses, and dogs, both in paste form and injectable liquid. Now I read the other day that it can be good for me, too. Who knew?

andesbill

I’m afraid the answer is no. It has to be injected. And please don’t try and inject the cream.

FranC

What company manufactures or sells the Ivermectin being considered for use with Covid-19?

St.Mary's

Whew. A lot of serious words being used here. I always like to learn new words, but I believe I will pass on most of these.

steve Loc: Iowa

Yes, interesting.

Merlin1300 Loc: New England, But Now & Forever SoTX

I cannot recommend ingesting medication intended for topical application. Topicals are compounded with many different components that may be harmful if taken internally.