I've often noticed a difference between horizontal and vertical. I use a 5dmiii and a canon speedlite. Looking forward to hearing from others as well.

That is funny.
I work for a printer in Louisiana and I just printed an rsvp card for a bride to be which had the following comment below the check boxes of if you were going to attend or not.
If you don't send the rsvp by the required date and decide to attend, please bring a chair and a sandwich.

I think I need to go back to school!

Let me simplify.
When I am up close taking a portrait using my 70-200 at close to 200mm, I should be able to count the eye lashes on my models eyes. If my micro adjust is dead on, I can repeatedly get those eye lashes sharp.
Like trix, straight out of the box my 70-200 was front focusing by almost 1/4 inch. After adjustment, I can hit it dead on every time. I use a simple cardboard calibration tool I mentioned earlier from eBay to get it right.

IMO I don't think she's the right subject for a grunge shot. A beautiful woman should be smoother to me. Grunge should apply to a cowboy, an old wrinkly man (or old woman). But not a young woman.
I also agree with bill p and jd750. She looks strained and not relaxed.
Drop the grunge and lower her right arm and keep everything else you've done, and I think you've got it!

I wish I had that one when I first got married. We only had the separate hot and cold faucets. You either had extremely hot on the left or extremely cold on the right. When brushing your teeth you had to put your hand under the cold first then under the hot to get a mixture comfortable enough to put in your mouth!

Go to eBay and search for lens focus calibration chart. They cost just a few bucks and work excellent. I've even gotten about 6 or 8 of them for under 10.00 for all. (I give one away every now and then) it has the angled measuring device with a flat piece to focus on. I keep it in my man cave with my photo equipment and take it out for every new lens I buy. Especially my 70-200 and my most recent purchase, the 100-400.

To answer your question, yes. It makes me queezy.

Tastes like chicken!
Kidding aside. Both very nice!

Don't know how far you already are into Lightroom, but I wish I had watched the video below before diving head first. It is a b&h video entitled, "adobe lightroom: the library module, Order from chaos"
It is 1:37:36 long and it is a good starting point for Lightroom. It's amazing how many people think they know how Lightroom operates and really don't have a clue. I still watch it every now and then to brush up.

https://youtu.be/VClhC8RaxTU

Where was this taken? Kind of looks familiar.

To me the picture doesn't depict your description. Perhaps a different angle?
I'm thinking moving to the left between the line of police and the line of demonstrators, and up a little higher than eye level.

And an excellent shot of it as well.

I copy a lot of art/photographs with a single shot with pretty good results.
I put my camera on a tripod and with the camera leveled on the tripod I place the tripod as close to the original on the wall.
I premeasure the original from top to bottom and place the middle of the lens smack dab on that point carefully adjusting the legs of the tripod till the camera is centered top to bottom. I then back the tripod and camera away from the original hanging on the wall until it almost fills the frame with a little to spare. I have grids turned on. ( I use a canon 5d mark iii)
I can then center it better from left to right. I have a large piece of black felt with a tiny hole (the size of my lens) cut out the exact center in which I have two people hold at the top two corners where i can look through my viewfinder to check for reflections. When I'm ready to take the shot, I turn on live view and magnify x10 and manually focus on my LCD for maximum sharpness. I shoot quite a few shots both on, over and under exposed. If I have not explained anything well enough, let me know and I will be happy to clarify.
Of course I have never done one as large as you need to do, but I have done some as big as a 2 ft x 3 ft.

Cute kid. I'll be happy to baby sit him when he is potty trained and can mow grass!