What may be causing allergic reactions to the Pfizer COVID vaccine
Dec 23, 2020 17:34:11 #
srscary
Loc: Cary, NC
Bonus content : the list of ingredients of the Pfizer and Moderna vaccines. A good test of how much HS and college chemistry you remember 😊
https://www.livescience.com/allergies-pfizer-coronavirus-vaccine.html
https://www.livescience.com/allergies-pfizer-coronavirus-vaccine.html
Dec 24, 2020 05:52:01 #
Did a quick peek.
It seems that PEG in other products through slow absorption via the stomach or skin has slowly caused people to have anti-PEG antibodies. Then the direct IV or IM dump cause a much more rapid reaction akin to (severe) allergy.
https://en.wikipedia.org/wiki/Polyethylene_glycol:
Health effects
PEG is considered biologically inert and safe by the FDA. However, a growing body of evidence shows the existence of a detectable level of anti-PEG antibodies in approximately 72% of the population, never treated with PEGylated drugs, based on plasma samples from 1990–1999.[37] The FDA has been asked to investigate the possible effects of PEG in laxatives for children. Since 1999, the FDA has received over 1,000 incident reports from parents reporting serious or life threatening side effects after their children were given one or more doses of PEG as an osmotic laxative.[38] Miralax has not been tested on children. PEG is not recommended to those under 18.
Due to its ubiquity in a multitude of products and the large percentage of the population with antibodies to PEG, hypersensitive reactions to PEG are an increasing concern.[39][40] Allergy to PEG is usually discovered after a person has been diagnosed with an allergy to an increasing number of seemingly unrelated products, including processed foods, cosmetics, drugs, and other substances that contain PEG or were manufactured with PEG.[39]
When PEG is chemically attached to therapeutic molecules (such as protein drugs or nanoparticles), it can sometimes be antigenic (a molecule which stimulates an immune response), stimulating an anti-PEG antibody response in some patients. This effect has only been shown for a few of the many available PEGylated therapeutics, but it has significant effects on clinical outcomes of affected patients.[41] Other than these few instances where patients have anti-PEG immune responses, it is generally considered to be a safe component of drug formulations.
It seems that PEG in other products through slow absorption via the stomach or skin has slowly caused people to have anti-PEG antibodies. Then the direct IV or IM dump cause a much more rapid reaction akin to (severe) allergy.
https://en.wikipedia.org/wiki/Polyethylene_glycol:
Health effects
PEG is considered biologically inert and safe by the FDA. However, a growing body of evidence shows the existence of a detectable level of anti-PEG antibodies in approximately 72% of the population, never treated with PEGylated drugs, based on plasma samples from 1990–1999.[37] The FDA has been asked to investigate the possible effects of PEG in laxatives for children. Since 1999, the FDA has received over 1,000 incident reports from parents reporting serious or life threatening side effects after their children were given one or more doses of PEG as an osmotic laxative.[38] Miralax has not been tested on children. PEG is not recommended to those under 18.
Due to its ubiquity in a multitude of products and the large percentage of the population with antibodies to PEG, hypersensitive reactions to PEG are an increasing concern.[39][40] Allergy to PEG is usually discovered after a person has been diagnosed with an allergy to an increasing number of seemingly unrelated products, including processed foods, cosmetics, drugs, and other substances that contain PEG or were manufactured with PEG.[39]
When PEG is chemically attached to therapeutic molecules (such as protein drugs or nanoparticles), it can sometimes be antigenic (a molecule which stimulates an immune response), stimulating an anti-PEG antibody response in some patients. This effect has only been shown for a few of the many available PEGylated therapeutics, but it has significant effects on clinical outcomes of affected patients.[41] Other than these few instances where patients have anti-PEG immune responses, it is generally considered to be a safe component of drug formulations.
Dec 24, 2020 14:59:47 #
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