Personally I favor the lowest iso (least noise), widest available aperture (most light), and raising the shutter speed until I see the best live view, with prominent shadows and minimized blown out areas.
Taken with the Coolpix B700. Iso-100, f6.5, 1/500 sec., focal length 361mm, equivalent focal length 1440mm, autofocus.
Thanks everyone for your input & comments. My thoughts would be to switch to manual focus & focus to infinity, f/11, [nothing to be concerned about the DOF Linda :~)], starting with ISO 200 and possibly going to 400, starting with ss of 1/250 and possibly trying one a bit slower & one a bit faster, and spot meter on the moon before each shot. This will be my first attempt at a moon shot. Comments?