The Best picture you will ever see is the one you see when your camera is in the trunk of your car!
I found it is much like having a phone in the car - too dangerous to pull it out some times.
I have used my camera harness with my bridge camera and kept it on when I have been"road shooting" in the mountains - not knowing what was around the next curve.
I know I will not do that with my DSLR with the 100-300 on it.
Best photo op I ever missed was at Lake Tahoe a couple of summers ago. The wife and I were driving down the road when we saw a young bear walking down the road. I pulled over and went to grab my camera which was in the back of my SUV. Meanwhile the bear was wandering through a construction site and jumped up onto a full dumpster. As I turned to raise my camera he had discovered a McDonalds bag and was holding it in his paws while standing in the dumpster. Just as I was about to take the pic a couple of construction workers yelled at him and scared him away. Last time I saw the bear he was headed up the driveway of a very expensive lake front home. Would have been a great shot had I been able to get it.
We always had Red tailed hawks living across the river on the side hill. One day I was planting and weeding on the river plain and heard a hawk's call, looking up I say one hawk flying up out of the trees. The hunter flew in with a squirrel/chipmunk in its talons. Like a pro basketball player it tossed it down to its mate, who "sat back" and snagged it in her talons. I didn't have my camera, but will forever remember the scene. It was extraordinary, had I been fussing with my SLR I probably would have missed it all.
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