Just Fred wrote:
Resident of (Northern) Virginia here. In my opinion, West Virginia is one of the most picturesque states east of the Mississippi. Route 64 is probably the longest time-wise, but it would take you through Tennessee (also very picturesque) into Virginia. If you wanted to see WV, there are plenty of side trips you could make. In my opinion, a direct west-to-east route would be rather boring, and only the best choice if time is an issue.
Correction - I64 traverses Kentucky, not Tennessee. The Bluegrass state offers as much beautiful scenery as my home state. So, if time is not an issue, taking that route would give plenty of opportunities to run your camera batteries down.
Edit: should’ve read all the posts first - sorry.