Larry, there is no doubt in my mind that you will do a
wonderful job on this challenge.

I also want to give a huge "Thank You" to Jim not only
for running "FREE SUNDAYS" for so many years, but
for everything he contributes to UHH!

That said, I like to "play" with images...hope you enjoy.

I wanted to share a little tutorial about eliminating camera noise at high ISO using Focus Stacking
I use Lightroom Classic & Photoshop CC 2018. This only works on stationary images and maybe portrait photos, but that's another experiment for another day.
I have four photos, first one was shot at ISO 6400, low light. Don't look at the mess. Everything here is stationary. This could be a cityscape, landscape or indoors where it's late very low light and the only way to shot would be a very long shutter speed or raise the ISO.
Please use the download feature to see the noise.
Second photo is a blown up area of showing the camera noise at ISO 6400.
Third photo is the same area after focus staking showing very little noise.
And finally the forth is the final produce full size to compare with photo one.

Setup your camera for proper exposure. For this experiment I took 14 shots. A shutter release really helps but not necessary. You can do this with a lot less photos but the more shots the better the results. Download all the images to your computer.

1. Open Photoshop. Open File-Scripts and select Load Files into Stack. (photo 5)

2. In the Load Layers Box, Select Browse and select all the photos and press open.
Note: This will work on all files including RAW (photo 6)

3. Check the "Attempt to Automatically Align Source Images"
click "OK". This will load each photo into a separate layer and align. (photo 7)

4. Select the top layer, Scroll down to the bottom layer, hold the "shift" key down and click on the bottom layer.
You should now have all the layers highlighted. (photo 8)

5. Open Layer-Smart Objects and select "Convert to Smart Object". you should now have one layer that is a smart object. (photo 9)

6. Here's where the magic happens.
Open Layer-Smart Objects-Stack Mode and select "Median" (photo 10)

That it. Simple. Hope this makes since. Any Questions either PM me or ask here. I'll be glad to help.

Larry, there is no doubt in my mind that you will do a
wonderful job on this challenge.

I also want to give a huge "Thank You" to Jim not only
for running "FREE SUNDAYS" for so many years, but
for everything he contributes to UHH!

That said, I like to "play" with images...hope you enjoy.