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Second Covid Shot
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Note: posting politics outside of the Attic is against UHH rules. Users that bring politics into this discussion will have their accounts banned from replying in this topic. Repeated violations will lead to account suspension.
 
Feb 19, 2021 12:02:20   #
spautocc
 
LEWHITE7747 wrote:
Just read an article that the Pfizer vaccine is 85% effective after the first dose (after 2 weeks). Has anyone seen this study.


True and to the point that they are thinking of going to just one shot so they can get more vaccinated.

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Feb 19, 2021 12:31:40   #
DebAnn Loc: Toronto
 
jerryc41 wrote:
I've been hearing a lot online and locally about people being very sick for a day or two after the second Covid shot (either kind). Many people experience nothing more serious than a sore arm, though. Our local school was closed for a few days because so many teachers had bad reactions to their second shot.

Have any of you gotten sick after the second one? I get my second on March 3. A friend got an appointment at a site two hours away, and then she got one locally. She's gong to try to go there with her husband and have him get the shot. She called and asked about it, and they said it's worth a try. Any opinions on that?
I've been hearing a lot online and locally about p... (show quote)


In Toronto, my turn for shots hasn't yet materialized. However, in the newspaper today, two prominent doctors say that the first shot has proved to be 80% effective (Pfizer) so they're advising the province to use more of the vaccine doses for more people and put off the second dose till a later time.

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Feb 19, 2021 12:38:04   #
David Martin Loc: Cary, NC
 
DebAnn wrote:
In Toronto, my turn for shots hasn't yet materialized. However, in the newspaper today, two prominent doctors say that the first shot has proved to be 80% effective (Pfizer) so they're advising the province to use more of the vaccine doses for more people and put off the second dose till a later time.

Again, if this figure is based on the Israeli study just published in Lancet (which found 85% efficacy), they only studied healthcare workers. Their 85% efficacy may not apply to the elderly, the significantly chronically ill, nor the very young. In medical research, it is not prudent to compare apples to oranges. See my last post above if you're interested.

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Feb 19, 2021 12:48:39   #
tomad Loc: North Carolina
 
I had absolutely nothing after the first shot and only a very slightly sore arm after the second shot. My arm only felt sore at the injection site for a day and only when I lifted my arm up over my head. That was the Pfizer shots.

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Feb 19, 2021 12:57:20   #
charles tabb Loc: Richmond VA.
 
jerryc41 wrote:
I've been hearing a lot online and locally about people being very sick for a day or two after the second Covid shot (either kind). Many people experience nothing more serious than a sore arm, though. Our local school was closed for a few days because so many teachers had bad reactions to their second shot.

Have any of you gotten sick after the second one? I get my second on March 3. A friend got an appointment at a site two hours away, and then she got one locally. She's gong to try to go there with her husband and have him get the shot. She called and asked about it, and they said it's worth a try. Any opinions on that?
I've been hearing a lot online and locally about p... (show quote)


I did just that...
I had an appointment to get my shot.
I'm 81 and they were only shooting 75 & over.
My wife is 74 and 6 MO"s from 75.
The person told me to bring her because they seem to have extra shots.
I did just that and they shot us both.

Charles

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Feb 19, 2021 13:14:23   #
neco Loc: Western Colorado Mountains
 
jerryc41 wrote:
I've been hearing a lot online and locally about people being very sick for a day or two after the second Covid shot (either kind). Many people experience nothing more serious than a sore arm, though. Our local school was closed for a few days because so many teachers had bad reactions to their second shot.

Have any of you gotten sick after the second one? I get my second on March 3. A friend got an appointment at a site two hours away, and then she got one locally. She's gong to try to go there with her husband and have him get the shot. She called and asked about it, and they said it's worth a try. Any opinions on that?
I've been hearing a lot online and locally about p... (show quote)


Had my second shot nine days ago. #2 had more after effects: chills, tired body, sore arm. Took a couple Ibuprofen and a nap and felt fine. I don't know if the fix was the nap or the pills. My two weeks wait will be up next Wednesday.

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Feb 19, 2021 13:15:25   #
LEWHITE7747 Loc: 33773
 
charles tabb wrote:
I did just that...
I had an appointment to get my shot.
I'm 81 and they were only shooting 75 & over.
My wife is 74 and 6 MO"s from 75.
The person told me to bring her because they seem to have extra shots.
I did just that and they shot us both.

Charles


So happy for both of you!

Reply
 
 
Feb 19, 2021 13:22:30   #
LEWHITE7747 Loc: 33773
 
David Martin wrote:
Again, if this figure is based on the Israeli study just published in Lancet (which found 85% efficacy), they only studied healthcare workers. Their 85% efficacy may not apply to the elderly, the significantly chronically ill, nor the very young. In medical research, it is not prudent to compare apples to oranges. See my last post above if you're interested.


What you have to understand as we are in the infancy of this vaccine research. It is known that we do not have the time for advanced studies. We only know what we know now. We have to move forward with the information we have. Everyone realizes that these are not detailed studies. In the past vaccines needed at least 4 years to develop and test. We are in the midst of a full blown pandemic. The plan to get the vaccine in the most arms as possible and approach herd immunity is the goal..It is a waste of time to quibble about the limited studies we have without the time frame of past vaccine research.

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Feb 19, 2021 13:23:24   #
Ferris Loc: South Carolina
 
Concerning managing the side effects: As mentioned in these posts, side effects similar to a flu-like illness occur primarily with the second injection. Acetaminophen (Tylenol) should handle these fairly well, by at least reducing their severity. Acetaminophen is not immunosuppressive and is not anti-inflammatory and thus should not affect the desired immune response needed for the vaccine to work. Aspirin and non-steroidal anti-inflammatory agents may reduce the side effects, but I cannot find any statement concerning whether these agents may actually reduce the effectiveness of the vaccine, but theoretically because they work by reducing inflammation, they may be reducing the body's response to the vaccine to some degree. So, I would think, until somebody studies this specifically, I would avoid aspirin and NSAIDs like ibuprofen to manage those side effects.

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Feb 19, 2021 13:25:03   #
LEWHITE7747 Loc: 33773
 
Ferris wrote:
Concerning managing the side effects: As mentioned in these posts, side effects similar to a flu-like illness occur primarily with the second injection. Acetaminophen (Tylenol) should handle these fairly well, by at least reducing their severity. Acetaminophen is not immunosuppressive and is not anti-inflammatory and thus should not affect the desired immune response needed for the vaccine to work. Aspirin and non-steroidal anti-inflammatory agents may reduce the side effects, but I cannot find any statement concerning whether these agents may actually reduce the effectiveness of the vaccine, but theoretically because they work by reducing inflammation, they may be reducing the body's response to the vaccine to some degree. So, I would think, until somebody studies this specifically, I would avoid aspirin and NSAIDs like ibuprofen to manage those side effects.
Concerning managing the side effects: As mentioned... (show quote)


Very good info!

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Feb 19, 2021 13:38:19   #
Bill_de Loc: US
 
David Martin wrote:
This is not exactly true.

The data Pfizer presented to the FDA stated that after dose #1, efficacy was estimated at 82%.

However, the observed efficacy after dose #1 and just before dose #2 was only 52.4%.

Pfizer concluded that their data "cannot support a conclusion on the efficacy of a single dose of the vaccine."

Here is a link to the full report Pfizer presented to the FDA:
https://www.fda.gov/media/144245/download

If anything, read the last paragraph on page 32.
This is not exactly true. br br The data Pfizer p... (show quote)


I think somewhere along the way some non-medical folks wanted to get more people vaccinated so the numbers would look better. To that end they claimed the first dose was so good that the second dose could be postponed. Of course that wasn't really true and AFAIK we are giving the second doses on time.

--

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Feb 19, 2021 13:40:27   #
MadMikeOne Loc: So. NJ Shore - a bit west of Atlantic City
 
David Martin wrote:
Here's a link to the Israeli study for those interested:
https://www.thelancet.com/action/showPdf?pii=S0140-6736%2821%2900448-7

They studied healthcare workers, whereas the Dec 10 Pfizer data was based on a broader spectrum of population demographics. It may not be appropriate to assume that the experience in healthcare workers may be applicable to the population at large. By definition, healthcare workers are young enough and healthy enough to work. The 85% efficacy in particular may not be applicable to the most vulnerable to Covid-19, namely the elderly and the significantly chronically ill. And may not apply to the very young. At least for now, the 85% efficacy only applies to healthcare workers and similar demographics.

What is needed is a study measuring both antibody levels and incidence of Covid-19 infection over 1 year in a broad spectrum cohort who receive only a single dose. Until then, the data are interesting, but not sufficient for generalized policy making.
Here's a link to the Israeli study for those inter... (show quote)


There is most definitely an awful lot that we don't know about this virus, its variants, and the vaccines. You are absolutely correct that we shouldn't generalize and that much more study must be done.

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Feb 19, 2021 13:47:31   #
MadMikeOne Loc: So. NJ Shore - a bit west of Atlantic City
 
Bill_de wrote:
I think somewhere along the way some non-medical folks wanted to get more people vaccinated so the numbers would look better. To that end they claimed the first dose was so good that the second dose could be postponed. Of course that wasn't really true and AFAIK we are giving the second doses on time.

--


My best friend (age 77) lives in the UK. She received her first dose of the Pfizer vaccine about 2 weeks ago, BUT as it stands right now, will not be receiving her second dose until 12 weeks post first dose. The government has decided to stretch the vaccine supply to vaccinate more people with the first dose. From my conversations with her, the government there is hoping that the supply of the vaccines will increase quickly enough to allow for some measure of administering the second doses "on time". I can tell you that I made absolutely certain that my husband and I received our second doses of the Moderna 28 days post-1st dose. It wasn't easy - took endless hours on the internet a setting up multiple portals on so many sites that we lost count.

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Feb 19, 2021 14:05:09   #
David Martin Loc: Cary, NC
 
LEWHITE7747 wrote:
What you have to understand as we are in the infancy of this vaccine research. It is known that we do not have the time for advanced studies. We only know what we know now. We have to move forward with the information we have. Everyone realizes that these are not detailed studies. In the past vaccines needed at least 4 years to develop and test. We are in the midst of a full blown pandemic. The plan to get the vaccine in the most arms as possible and approach herd immunity is the goal..It is a waste of time to quibble about the limited studies we have without the time frame of past vaccine research.
What you have to understand as we are in the infan... (show quote)

I'm well aware of vaccine development history, our current status and goal of herd immunity.
I am also aware of how dangerous it is to take limited research data, obtained from a small, non-representative subset of population, and generalize it to the population at large.
Therein lies the danger. And if there is possible danger, it is quite prudent to "quibble" about potentially bad decisions.
On what scientific basis do we assume that the very young, the elderly and those with severe chronic illness will develop the same level of immunity to a single shot that younger, healthy individuals may get?
If it turns out that they do not develop immunity, are they dispensable for the "greater good" of getting more shots into more arms?
It is best to follow sound science and not make such assumptions.

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Feb 19, 2021 14:10:38   #
SweetPea
 
ELNikkor wrote:
My wife was sick after her first (Pfizer). When they called her to come back for her second 3 weeks later, she went, but they wouldn't give it to her. (They said she wasn't in their system, even though they were the ones who had made the appointment!) Now, 8 weeks later (too late for the second one) they just called her and said she could come in for the second one again, (but she'd have to start over with the first one again, as too much time has passed!) Needless to say, she's skipping the whole thing and good riddance to it.
My wife was sick after her first (Pfizer). When t... (show quote)

She should have showed them her vaccination card from her first shot!

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