For the last 10 years, I have lived in Greenville. Depending upon what you like to shoot, there is downtown in the evening, waterfalls abound in both SC and western NC. The various national forests have some beautiful areas. Table Rock SP at the lake is very photogenic. For flowers and an old cabin the SC Botanical Gardens at Clemson. Further afield for wading birds is Huntington Beach SP.
Just a quick sample.
Isn't there a place called "Twin Falls" that may not be on a map, but the locals know?